Tuesday, 10th February 51st Lorne Proteins Conference 2026

If you're staying at Mantra Lorne, breakfast is included in your accommodation booking.

If you're staying offsite, you're most welcome to join us. Coffee is available for purchase at the counter in the restaurant. Breakfast is $34/person.

• Structural Pharmacology of Na_v and Ca_v channels - Nieng Yan
• Structural basis of bacterial nickel import by Type I ABC transporters - Emily J. Furlong
• Mechanistic and Structural Insights into Heteromeric Amino Acid Transporters for Rational Drug Design - Renhong Yan
• Understanding the role of SLCs in chronic pain in the human body - Simon Newstead

• Unravelling promiscuity: Molecular determinants of drug transport in human Organic Cation Transporter 1 - Yi C Zeng
• Structures, dynamics and function of PAC1 receptor variants: staying 'in the loop'. - Sarah J Piper
• Learning to walk: the first steps of an artificial protein motor - Neil Robertson
• Structural innovations in bacterial stators drive functional diversity and specialisation - Caroline Puente-Lelievre
• High-resolution cryo-EM using a common 120-keV LaB₆ electron microscope equipped with a sub–200-keV direct electron detector. - Hariprasad Venugopal
• Structural and Antigenic Diversity of Emerging Japanese Encephalitis Virus Genotypes  - Naphak Modhiran
• Probing allosteric activation in GPCRs with rigidity transmission allostery (RTA) theory, NMR, and simulations - Adnan Sljoka
• HLA-A*03:01 association with COVID-19 vaccine side effect is T cell activation independent - Dimitra SM Chatzileontiadou

• Small Molecule Transport for Life - David Drew

Presented by

• TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience - Yiechang Lin
• The Basis of Phospholipid Transport to the Bacterial Outer Membrane by the Translocation and Assembly Module - Lachlan S R Adamson
• Structural and Functional Characterisation of NLS Recognition by Toxoplasma gondii Importin α - Diksha Mehta
• A structural perspective on pore formation and regulation of Bacteroides fragilis toxins. - Riya Joseph

• Fighting Parkinson’s Disease with…Beer? Conformational Modulation of α-synuclein Aggregation Dynamics by Extracts of Brewer’s Spent Grain - Rebekah Munro
• Influence of proline-rich regions on the assembly and function of autotransporters from enteric pathogens - Amina Mustafa
• Structure of the autotransporter adhesin RadD from Fusobacterium nucleatum - Sathya Muthusamy
• Characterizing the mechanistic determinants of zinc efflux in Streptococcus pneumoniae CzcD - Salma SF Naleem Farook
• Cracking the entry code: How does phage DNA get beyond the peptidoglycan layer? - Kishani N Naligama
• Exploiting tau amyloid polymorphism for diagnosis of chronic traumatic encephalopathy (CTE) - Joanna L New
• Investigating allosteric modulation at the delta opioid receptor (DOR) - Mai Deborah Nguyen
• Evaluation of Biofunctional Properties of AstaP, a Novel Water-Soluble Astaxanthin-binding Protein from Coelastrella astaxanthina Microalgae - Istiani Novitasari
• Uncovering novel flagellar proteins in the S-layer containing Gram-positive bacterium, Bacillus solimangrovi - Isa Nuryana
• Allosteric modulators at the D2R - Caitlin Owyong
• Structural Insights into KvrA: A MarR Homologue that Senses and Responds to Copper Stress - Stephanie Penning
• Structural and Functional Characterisation of AfuCys1a: An Adjuvant Target in the Cysteine Biosynthesis Pathway of Aspergillus fumigatus - Isis I Pinner
• THE DESIGN OF CHD4-BINDING PEPTIDES FOR THE TREATMENT OF HEMOGLOBINOPATHIES   - Sebastian Abby Pratama
• The lipid fingerprint of inward facing ABCG2 reveals cholesterol interaction hotspots - Ada Quinn
• Structural and Pharmacological Basis of Allosteric Modulation at the M₅ Muscarinic Acetylcholine Receptor - Bhavika Rana
• Structure of an avian integral membrane αβT-cell receptor-CD3 complex - Liam Rashleigh
• Structural Analysis of Novel Archaeal Viruses - Milad Reyhani
• Activation of the GABA_B Receptor by Conopeptides and Orthosteric Agonists. - David Safadi
• A twist in nitrogen metabolism: Guanidine binding recognised by a predicted nitrate binding protein in marine picocyanobacteria. - Anushka Vidurangi Samaraweera
• BAM-Boozled: Pyocin L1 and Darobactin Disrupt Outer Membrane Protein Assembly in Pseudomonas aeruginosa - Imogen Samuels
• Establishing the interaction network of calcium and integrin binding proteins using ASAP-ID a novel proximity labelling approach - Katrina L Schiller
• Can an Ag43-specific Small Protein Fragment Inhibit the Biological Function of Autotransporter, Ag43? - Hunter Seabrook
• Investigating the structural basis of effector delivery through a bacterial Type IV Secretion System - Doulin Shepherd
• Exploring the mitochondrial co-translational insertion machinery - Benedicta Sherrie
• Filamentous assemblies of bacterial TIR-domain induced by NAD+ analogue and nucleic acids - Jieyu Song
• Phage resistance to broad host range Klebsiella targeting bacteriophages evolves via changes to conserved LPS core structures and large deletions. - Dillon Spark
• Ribosomal methylation remodels metal–ribosome interactions and translational adaptation in Saccharomyces cerevisiae - Andrew J Spiteri
• Studying the retromer complex and its interaction with the rab gtpase activating protein tbc1d13 - Ella Stephens
• Direct Drugging of the p53 TAD with a De Novo Designed Protein - Alexander Stevens
• Catch of the day: Substrate binding proteins in the uptake of amino acids and alternative nutrients in marine picocyanobacteria - Alexandra Stute
• Phage morphology and cell wall hydrolase play a role in phage infection of Gram-positive Staphylococcus - Sabrina Suhani
• The structural and pharmacological characterisation of the neuropeptide s receptor 1 - Feng (Ruby) Tang
• Analytical Ultracentrifugation The solution is... spinning the solution - Zachary David Tillett
• Investigating the interaction of BET proteins with acetylated transcription factors - Simone Titterton
• Defining the Role of MSP4 in Plasmodium falciparum Merozoite Invasion and Its Potential as a Therapeutic Target - Jarryd B Tiu
• An investigation into the structure, function, and therapeutic potential of the choline transporter FLVCR2 - Matthew MTV van der Burg
• A PPAR-fect Match? Developing Novel Peroxisome Proliferator Activated Receptor γ Ligands with High Affinity and Low Transactivation - Samuel L. Wallis
• FROM DEATH COMES LIFE: CONTROL OF THE PROGRAMMED CELL DEATH PATHWAY NECROPTOSIS VIA FUNCTIONAL AMYLOID FIBRILS - Brayden Williams
• The First Pore Structure of an Independent and Insecticidal Bacterial Exotoxin B protein Vpb4 - Raymond Wirawan
• Structural and Functional Studies of Zinc Resistance Associated Proteins (ZraP) from Klebsiella pneumoniae and Escherichia coli - Haozhe Wu
• A Unified Framework for Measuring and Mapping Local Conformational Flexibility - Junjie Xu
• NanoAAI: An Interpretable Sequence–Structure Framework for Nanobody–Antigen Interaction Prediction - Shuting Xu
• Structural and functional investigation of DesC and DesD for the biosynthesis of novel multimeric siderophores - Jiarui Yan
• Structural basis of positive allosteric modulator selectivity at the muscarinic acetylcholine receptors - Mahmuda Yeasmin
• Leukocyte Immunoglobulin-Like Receptor B1 and its interactions with Human Leukocyte Antigens - Geoff Zhang
• Title: Structural basis of bitopic ligands at the M1 muscarinic acetylcholine receptor. - JIAYIN ZHANG
• Alternative Splicing of Mitochondrial Fission GTPase DRP1 Generates Distinct Metabolic and Lipid Sensitivities - Lifang Zhang
• Structure and function of NanOU, an outer membrane sialic acid transporter - Ruosong Zhang
• Structural and functional characterization of γ-carbonic anhydrase from Klebsiella pneumoniae - Peiyuan Zhao
• The molecular mechanism of action of the endocytosis inhibitor dynole 34-2 on dynamin - Philip Zhong
• Molecular mechanisms of trafficking and processing of lipid antigens by human CD1e - Jingsong Zhou
• Structural characterisation of SIN3’s PAH domains and their interaction with MNT - Bhagya Mendis
• Optimising PolyC9 for Ultra-Fast Gene Detection technologies   - Jack Norris

• Adaptive Capacity of a DNA Polymerase Clamp Loader - John Kuriyan

• Mechanistic Insights into the Activation and Pore Formation of Insecticidal Proteins from Ferns - Nadezhda A Aleksandrova
• Unravelling the Structural Mechanism of the Pneumococcal Manganese Transporter PsaBCA - Bryan Y.J. Lim
• Engineering pH-Responsive IgG Cytosol Penetrating Antibodies for Intracellular Targeting and Therapeutic Payload Delivery - Yong-Sung Kim
• Computational studies of PA14 of LacdiNAc synthase B4GALNT3 as a lectin domain that binds to sulfated glycan ligands - Robert J Doerksen
• sRNAs, The Jack of All Trades in Bacteria Optimizing Growth and Minimizing Energy Costs Through Post-transcriptional Regulation. - Kwok Jian Goh
• Functional importance of a post-translational succinimide modification in a high-affinity solute-binding protein - Ben E Clifton
• Structural arrangement and activation of the KDEL receptors - Yi C Zeng
• Structural and functional insights into two oxygen-tolerant membrane [NiFe] hydrogenases - Marion Jespersen
• Classical and neural models of protein sequence evolution - Ian Holmes
• Using minicells to examine B-barrel protein arrays in Klebsiella pneumoniae - Cara Press
• De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3 - Jessica A Buchanan
• Navigating Chemical Space: A New Version of the C6 Webtool - Sophia Newton
• Navigating and Smoothing Complex Protein Fitness Landscapes for Generative Design   - Colin J Jackson
• De novo design of protein inhibitors and emergence of a scalable AI-driven protein design pipeline - Cyntia Taveneau
• Structural Insights into A Novel Chi-like Phage Targeting Multiple Klebsiella spp - Yan Li
• Structural insights into hERG channel inactivation revealed from CnERG1 scorpion toxin binding - Elaine Tao
• New structure of full-length MLKL reveals novel interface for interdomain communication - Katherine Davies
• Functional membrane proteins - ready in 48 hours; fast-tracking drug discovery with optimized, cryo-EM ready MsbA and ZMPSTE24 using the eProtein discovery™ system - Vicki Sifniotis
• Tripartite Efflux Pumps in Gram-positive bacteria? - Christopher J Stubenrauch
• Novel inhibitors targeting the Gram-negative bacterial two-partner secretion system. - Matthew Doyle
• Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex - Chris J Lupton
• Structural elucidation of peptide hormone amyloid fibrils via cryo-EM - Aidan B Grosas
• May the growth be with you: transferrin delivery for serum free culture via Camelina - Mike Norman
• Architecture of the dimeric GATOR1-KICSTOR complex - Charles Bayly-Jones
• Exploring TRPV4-driven molecular networks: Emerging roles in macrophage metabolic regulation - Nicholas A Veldhuis
• Advanced injection tools enable the study of complex biological processes   - Emma Dal Maso
• Phage-display methodology to enhance stability and selectivity of chemokine targeting evasin. - Pramish Mainali