Tuesday, 10th February 51st Lorne Proteins Conference 2026

• ^{Structural Pharmacology of Na_v and Ca_v channels} - Nieng Yan
• Structural basis of bacterial nickel import by Type I ABC transporters - Emily J. Furlong
• Mechanistic and Structural Insights into Heteromeric Amino Acid Transporters for Rational Drug Design - Renhong Yan
• Understanding the role of SLCs in chronic pain in the human body - Simon Newstead

• Unravelling promiscuity: Molecular determinants of drug transport in human Organic Cation Transporter 1 - Yi C Zeng
• Structures, dynamics and function of PAC1 receptor variants: staying 'in the loop'. - Sarah J Piper
• Learning to walk: the first steps of an artificial protein motor - Neil Robertson
• Structural innovations in bacterial stators drive functional diversity and specialisation - Caroline Puente-Lelievre
• High-resolution cryo-EM using a common 120-keV LaB₆ electron microscope equipped with a sub–200-keV direct electron detector. - Hariprasad Venugopal
• Structural and Antigenic Diversity of Emerging Japanese Encephalitis Virus Genotypes  - Naphak Modhiran
• Probing allosteric activation in GPCRs with rigidity transmission allostery (RTA) theory, NMR, and simulations - Adnan Sljoka
• HLA-A*03:01 association with COVID-19 vaccine side effect is T cell activation independent - Dimitra SM Chatzileontiadou

• Small Molecule Transport for Life - David Drew

Presented by

• TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience - Yiechang Lin
• The Basis of Phospholipid Transport to the Bacterial Outer Membrane by the Translocation and Assembly Module - Lachlan S R Adamson
• Structural and Functional Characterisation of NLS Recognition by Toxoplasma gondii Importin α - Diksha Mehta
• A structural perspective on pore formation and regulation of Bacteroides fragilis toxins. - Riya Joseph

• Fighting Parkinson’s Disease with…Beer? Conformational Modulation of α-synuclein Aggregation Dynamics by Extracts of Brewer’s Spent Grain - Rebekah Munro
• Influence of proline-rich regions on the assembly and function of autotransporters from enteric pathogens - Amina Mustafa
• Structure of the autotransporter adhesin RadD from Fusobacterium nucleatum - Sathya Muthusamy
• Characterizing the mechanistic determinants of zinc efflux in Streptococcus pneumoniae CzcD - Salma SF Naleem Farook
• Cracking the entry code: How does phage DNA get beyond the peptidoglycan layer? - Kishani N Naligama
• Exploiting tau amyloid polymorphism for diagnosis of chronic traumatic encephalopathy (CTE) - Joanna L New
• Investigating allosteric modulation at the delta opioid receptor (DOR) - Mai Deborah Nguyen
• Evaluation of Biofunctional Properties of AstaP, a Novel Water-Soluble Astaxanthin-binding Protein from Coelastrella astaxanthina Microalgae - Istiani Novitasari
• Uncovering novel flagellar proteins in the S-layer containing Gram-positive bacterium, Bacillus solimangrovi - Isa Nuryana
• Allosteric modulators at the D2R - Caitlin Owyong
• Structural Insights into KvrA: A MarR Homologue that Senses and Responds to Copper Stress - Stephanie Penning
• Structural and Functional Characterisation of AfuCys1a: An Adjuvant Target in the Cysteine Biosynthesis Pathway of Aspergillus fumigatus - Isis I Pinner
• THE DESIGN OF CHD4-BINDING PEPTIDES FOR THE TREATMENT OF HEMOGLOBINOPATHIES   - Sebastian Abby Pratama
• The lipid fingerprint of inward facing ABCG2 reveals cholesterol interaction hotspots - Ada Quinn
• Structural and Pharmacological Basis of Allosteric Modulation at the M₅ Muscarinic Acetylcholine Receptor - Bhavika Rana
• Structure of an avian integral membrane αβT-cell receptor-CD3 complex - Liam Rashleigh
• Structural Analysis of Novel Archaeal Viruses - Milad Reyhani
• Activation of the GABA_B Receptor by Conopeptides and Orthosteric Agonists. - David Safadi
• A twist in nitrogen metabolism: Guanidine binding recognised by a predicted nitrate binding protein in marine picocyanobacteria. - Anushka Vidurangi Samaraweera
• BAM-Boozled: Pyocin L1 and Darobactin Disrupt Outer Membrane Protein Assembly in Pseudomonas aeruginosa - Imogen Samuels
• Establishing the interaction network of calcium and integrin binding proteins using ASAP-ID a novel proximity labelling approach - Katrina L Schiller
• Can an Ag43-specific Small Protein Fragment Inhibit the Biological Function of Autotransporter, Ag43? - Hunter Seabrook
• Investigating the structural basis of effector delivery through a bacterial Type IV Secretion System - Doulin Shepherd
• Exploring the mitochondrial co-translational insertion machinery - Benedicta Sherrie
• Filamentous assemblies of bacterial TIR-domain induced by NAD+ analogue and nucleic acids - Jieyu Song
• Phage resistance to broad host range Klebsiella targeting bacteriophages evolves via changes to conserved LPS core structures and large deletions. - Dillon Spark
• Ribosomal methylation remodels metal–ribosome interactions and translational adaptation in Saccharomyces cerevisiae - Andrew J Spiteri
• Studying the retromer complex and its interaction with the rab gtpase activating protein tbc1d13 - Ella Stephens
• Direct Drugging of the p53 TAD with a De Novo Designed Protein - Alexander Stevens
• Catch of the day: Substrate binding proteins in the uptake of amino acids and alternative nutrients in marine picocyanobacteria - Alexandra Stute
• Phage morphology and cell wall hydrolase play a role in phage infection of Gram-positive Staphylococcus - Sabrina Suhani
• The structural and pharmacological characterisation of the neuropeptide s receptor 1 - Feng (Ruby) Tang
• Analytical Ultracentrifugation The solution is... spinning the solution - Zachary David Tillett
• Investigating the interaction of BET proteins with acetylated transcription factors - Simone Titterton
• Defining the Role of MSP4 in Plasmodium falciparum Merozoite Invasion and Its Potential as a Therapeutic Target - Jarryd B Tiu
• An investigation into the structure, function, and therapeutic potential of the choline transporter FLVCR2 - Matthew MTV van der Burg
• A PPAR-fect Match? Developing Novel Peroxisome Proliferator Activated Receptor γ Ligands with High Affinity and Low Transactivation - Samuel L. Wallis
• FROM DEATH COMES LIFE: CONTROL OF THE PROGRAMMED CELL DEATH PATHWAY NECROPTOSIS VIA FUNCTIONAL AMYLOID FIBRILS - Brayden Williams
• The First Pore Structure of an Independent and Insecticidal Bacterial Exotoxin B protein Vpb4 - Raymond Wirawan
• Structural and Functional Studies of Zinc Resistance Associated Proteins (ZraP) from Klebsiella pneumoniae and Escherichia coli - Haozhe Wu
• A Unified Framework for Measuring and Mapping Local Conformational Flexibility - Junjie Xu
• NanoAAI: An Interpretable Sequence–Structure Framework for Nanobody–Antigen Interaction Prediction - Shuting Xu
• Structural and functional investigation of DesC and DesD for the biosynthesis of novel multimeric siderophores - Jiarui Yan
• Structural basis of positive allosteric modulator selectivity at the muscarinic acetylcholine receptors - Mahmuda Yeasmin
• Leukocyte Immunoglobulin-Like Receptor B1 and its interactions with Human Leukocyte Antigens - Geoff Zhang
• Title: Structural basis of bitopic ligands at the M1 muscarinic acetylcholine receptor. - JIAYIN ZHANG
• Alternative Splicing of Mitochondrial Fission GTPase DRP1 Generates Distinct Metabolic and Lipid Sensitivities - Lifang Zhang
• Structure and function of NanOU, an outer membrane sialic acid transporter - Ruosong Zhang
• Structural and functional characterization of γ-carbonic anhydrase from Klebsiella pneumoniae - Peiyuan Zhao
• The molecular mechanism of action of the endocytosis inhibitor dynole 34-2 on dynamin - Philip Zhong
• Molecular mechanisms of trafficking and processing of lipid antigens by human CD1e - Jingsong Zhou
• Structural characterisation of SIN3’s PAH domains and their interaction with MNT - Bhagya Mendis
• Optimising PolyC9 for Ultra-Fast Gene Detection technologies   - Jack Norris

• Adaptive Capacity of a DNA Polymerase Clamp Loader - John Kuriyan

• Mechanistic Insights into the Activation and Pore Formation of Insecticidal Proteins from Ferns - Nadezhda A Aleksandrova
• Unravelling the Structural Mechanism of the Pneumococcal Manganese Transporter PsaBCA - Bryan Y.J. Lim
• Engineering pH-Responsive IgG Cytosol Penetrating Antibodies for Intracellular Targeting and Therapeutic Payload Delivery - Yong-Sung Kim
• Computational studies of PA14 of LacdiNAc synthase B4GALNT3 as a lectin domain that binds to sulfated glycan ligands - Robert J Doerksen
• sRNAs, The Jack of All Trades in Bacteria Optimizing Growth and Minimizing Energy Costs Through Post-transcriptional Regulation. - Kwok Jian Goh
• Functional importance of a post-translational succinimide modification in a high-affinity solute-binding protein - Ben E Clifton
• Structural arrangement and activation of the KDEL receptors - Yi C Zeng
• Structural and functional insights into two oxygen-tolerant membrane [NiFe] hydrogenases - Marion Jespersen
• Classical and neural models of protein sequence evolution - Ian Holmes
• Using minicells to examine B-barrel protein arrays in Klebsiella pneumoniae - Cara Press
• De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3 - Jessica A Buchanan
• Navigating Chemical Space: A New Version of the C6 Webtool - Sophia Newton
• De novo design of protein inhibitors and emergence of a scalable AI-driven protein design pipeline - Cyntia Taveneau
• Structural Insights into A Novel Chi-like Phage Targeting Multiple Klebsiella spp - Yan Li
• Structural insights into hERG channel inactivation revealed from CnERG1 scorpion toxin binding - Elaine Tao
• New structure of full-length MLKL reveals novel interface for interdomain communication - Katherine Davies
• Functional membrane proteins - ready in 48 hours; fast-tracking drug discovery with optimized, cryo-EM ready MsbA and ZMPSTE24 using the eProtein discovery™ system - Vicki Sifniotis
• Tripartite Efflux Pumps in Gram-positive bacteria? - Christopher J Stubenrauch
• Novel inhibitors targeting the Gram-negative bacterial two-partner secretion system. - Matthew Doyle
• Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex - Chris J Lupton
• Structural elucidation of peptide hormone amyloid fibrils via cryo-EM - Aidan B Grosas
• May the growth be with you: transferrin delivery for serum free culture via Camelina - Mike Norman
• Architecture of the dimeric GATOR1-KICSTOR complex - Charles Bayly-Jones
• Exploring TRPV4-driven molecular networks: Emerging roles in macrophage metabolic regulation - Nicholas A Veldhuis
• Advanced injection tools enable the study of complex biological processes   - Emma Dal Maso
• Phage-display methodology to enhance stability and selectivity of chemokine targeting evasin. - Pramish Mainali