Monday, 9th February 51st Lorne Proteins Conference 2026

•   Navigating and Smoothing Complex Protein Fitness Landscapes for Generative Design   - Colin J Jackson
• A protein antibiotic inhibits the BAM complex to kill without cell entry - Fabian Munder
• Structural remodeling of flagella promotes biofilm formation in oral pathogen Treponema denticola - Luca Troman
• Mechanism of inner-to-outer membrane remodeling  - Elitza Tocheva

• Unusual proteins and cellular architecture in Asgard archaea: clues to eukaryotic origins - Katharine A Michie
• Azaca antiphage defence systems sense hypermodified viral DNA - Gavin J. Knott
• Monitor and modulate the pathological aggregation of protein condensates - Yi Shen
• The unexpected double life of PfFNT: a transporter without conformational changes that can secretly operate as a channel - Ben Corry

Speaker: Eric Chen

We will discuss our latest CryoTEM the Krios 5 as a premier platform for in vivo and in situ structural biology along with several application  examples for basic and translational science. This will include a short segment on mass spec + CryoEM for small molecule protac drug discovery try workflows.

Presented by:

• Charting marine organosulfur metabolism: discovery of a homotaurine breakdown pathway - Helen Barber
• Characterization of oxygen-tolerant [FeFe]-hydrogenases and functional analysis of CbA5H-based variants  - Lisa Barbieri
•    Enhancing the plasma half-life of broad-spectrum chemokine binding tick proteins by fusion to XTEN tags for use as anti-inflammatory drugs   - Mikaela Bell
• Structural and pharmacological characterisation of CXCR3 isoforms and their modulation by therapeutic antagonists - Ania AB Beyger
• Characterisation of a novel bacterial dynamin-like protein pair of Helicobacter pylori (Hp-Bdlp1 and Hp-Bdlp2) - Avigya Bhattarai
• Structures and mechanisms of tRNA-cleaving by CRISPR-Cas13 effectors - Roland W Calvert
• Generating receptor-specific nanobodies - Maggie Cao
• Elucidating the molecular mechanisms of the orphan transporter MFSD14A - Bronte Carroll
• Bridging sequence and structure: A hybrid AI model for calcium channel variant pathogenicity - Wissuta Chinnawongsuwan
• Transforming Tools of Pathogenesis into Platforms for Therapeutic Delivery - Kait Clarke
• AI-Guided De Novo Protein Binder Design Targeting RXFP1: A Computational-to-Experimental Pipeline - Janik JC Clement
• The Cis-Proline Lock: A Conserved Scaffold for Catalysis in Thioredoxin-Fold Oxidoreductases - Taylor Cunliffe
• Crossing the barrier: Understanding the life cycle of membrane-containing phages at molecular resolution. - Somavally Dalvi
• Structural, kinetic and biophysical characteristisation of the Plasmodium aminopeptidase P - Kajal Daware
• Mechanistic Insights in DNA Transfer during Bacterial Conjugation - Mario Delgadillo Guevara
• Is CI wheel-y a 14mer? Cryo-EM analysis of bacteriophage 186 repressor CI oligomerisation - Sarah Eisemann
• A large-scale, AlphaFold2-based screen for Rab GTPase interacting partners reveals novel Rab effectors and GAPs - Denaye N Eldershaw
• Development of AI-designed protein binders for the inhibition of the AHPND causing Vibrio parahaemolyticus PirAB toxin - William Elliott
• Structural and Functional Studies of p63 Reveal a Unique, Mutation-Tolerant Mechanism for Nuclear Import - Sara Esmaeili
• Peering into a portal: Cryo-EM structure of a Finegoldia magna phage portal protein - Madeline Fechner
• From Structure to Selectivity: Cryo-EM Analysis of Ligand Binding in Human Kv7.5 Ion Channels - Thomas H Ficker
• Syndirella: Synthesis-directed fragment elaboration enables extensive binding site exploration beyond catalog compounds - Kate Fieseler
• AI-designed protein inhibitors can block hemoglobin binding and inhibit growth of pathogenic E. coli - Daniel R. Fox
• Investigation of the heme export pathway in mammalian mitochondria - Nicholas J Frescher
• Pathways mediating telocin (toxin) secretion in Klebsiella - Lu Gan
• Structural characterization of FLVCR1 in its outward-facing conformation - Ruohua Gao
• Cryo-EM Structure of Mycobacterium tuberculosis Acetohydroxyacid synthase Guides Repurposing of Herbicides as Novel Anti-TB Agents   - Yanhua Gao
• STRUCTURAL BASIS FOR PATHOGEN EFFECTORS RECOGNITION BY FLAX L6 IMMUNE RECEPTOR - Laura Garzon-Flores
• Exploring the Interaction Between Annexin A11 and TDP-43: Structural Insights into Self- and Co-Assembly Mechanisms   - Andrea Gelardo Serrano
• Characterisation of the protein-protein complex formed by the zinc binding proteins PA4063 and PA4066 from Pseudomonas aeruginosa - Josephine Goodall
• Minimalist bacteriophage Ptero and bat associated host: A unique phage with a unique origin - Alex Hall
• Computational Lipidomics Reveals Environment-Specific Membrane Remodeling in Prostate Cancer - Yumeng Hao
• AI-driven design of cyclical PCNA-targeting peptides - Dayna L Holroyd
• Understanding the impact of polyglucosan body myopathy type 1 (PGBM1) associated mutations on HOIL-1 function - Guoyuan Hong
• Understanding the molecular basis of ligand interactions with MFSD2A - Ariana Ivanic
• Structural clustering of the proteomes of a family of archaeal Borg-like extra-chromosomal elements enabled functional annotation of hypothetical proteins and phylogenetic inference - Natasha J Jablonsky
• Structural characterisation of INPP4B: insights into the final unsolved human phosphoinositide phosphatase family - Gareth Jones
• Discovery of Oxygen-Stable [FeFe]-Hydrogenases in Human Gut Bacteroides - Warunika Karunasiri
• An open to active clamshell mechanism for small RNA cleavage by a new conserved ribonuclease family - Kai Katsuya Gaviria
• Discovery of a novel dimerisation domain in PWWP2A/B - Erekle Kobakhidze
• Characterisation and drug discovery targeting PfSET7, a motility-associated lysine methyltransferase in Plasmodium falciparum - George Kobakhidze
• A Twist in the Tail: The Structural Basis of Kv7.2/Kv7.3 M-channel Assembly at Helix D - MariaKatarina Lambourne
• How T6SS(Type 6 secretion system) Delivers Rhs Effectors: Insights into Structure and Mechanism - Jiayu Li
• The dual role of Liquid-liquid phase separation in the Fibrillation of Murine RIPK3 RHIM - Tianchen Li
• Structural and functional characteristics of Legionella effector targeting mitochondria - Yee Wa Lim
• Mapping the unseen structural diversity of hydrogenases in silico  - James P Lingford
• Characterisation of Novel COMMD-Like Proteins from Archaea and Bacteria - Meihan Liu
• Characterising the interplay between MlaD and MlaC from Acinetobacter baumannii, and their interactions with phospholipids - Jiansi Long
• Characterisation of dihydroceramide desaturase (DES1) regulation - Thomas A. Lymburn
• Exploring the role of zinc and heme binding to the intrinsically disordered NTD of FLVCR2 - Parteek Mandhan
• Investigating Axundead, a potent regulator of Wallerian degeneration - Helen Y McGuinness
• Investigating the role of Nucleophosmin 1 condensates in acute myeloid leukemia - Sadananda Moirangthem Singh
• The pore-forming mechanism of an ABC toxin - Solace Roche
• The modular evolution of chitinases is governed by coevolution of auxiliary and catalytic domains. - Sacha B Pulsford

• A novel and widespread mechanism of membrane-coupling drives microbial respiration - Ashleigh Kropp
• One high-order ion coupling mechanism generates multiple SLC1A stoichiometries - Yan Jiang
• Receptor put to rest: The structure and dynamics of an arrestin-GPCR complex   - Brian Cary
• Capturing viral membrane fusion by cryo-ET using an in vitro reconstitution workflow - Bronte A Johnstone

• Copper palladium catalyzed synthesis of boryl substituted monofluoroalkenes - AYMAN M. Y. SULIMAN
• Protein Interactions to Particles: Mechanistic Studies of Virus-Like Assembly - Aakhya Rastogi
• Stability in Diversity: Exploring the Structural Impact of Antibody Polymorphisms - Annmaree K Warrender
• Shape Up Your Science: Structural Insights with BioSAXS - Annmaree Warrender
• ProteinDJ: a high-performance and modular protein design pipeline - Joshua M Hardy
• One Fragment Many Solutions - Michael D Healy
• γδ T cell receptor recognition of CD1d in a lipid independent manner - Michael T Rice
• Knowledge-based machine learning enables accurate chemical reaction prediction - Qisheng Pan
• Substrate bound cryoEM structures reveal CRISPR-Cas13 specifically cleaves tRNA to provide bacterial immunity. - Brooke K Hayes
• Multi-Chemokine Targeting Strategies to Tackle Immune System Complexity - Ram Bhusal
• Investigating quantum coherence in cryptophyte light-harvesting via cryo-electron microscopy and molecular dynamics simulations - Gesa Gruening
• Structure-Function Guided Development of P2X1 Receptor Small Molecule Antagonists for Use as a Non-Hormonal Male Contraceptive - Felix M Bennetts
• p53 Amyloids in Alzheimer's Disease - David Lynch
• New insights for an old target: Profiling spatiotemporal signalling of the tachykinin receptor NK1R - Nicholas A Veldhuis
• Structome-DeepRoots: On phylogenetic inference using high-dimensional embeddings - Ashar Malik
• Deciphering an integrated actin regulatory circuit coordinated by the SNX27-Retromer-WASH complex and the Rab13-MICAL-L2 signalling axis - Qian Guo
• Single-molecule assay for studying artificial protein motors - Zuzana Coculova
• Rapid characterization of nanobody-target interactions using Biacore™ cap-tag capture kit - Emma Dal Maso
• A Biophysical Study of Fluorinated Ligand Protein Recognition  - Paul Matthay
• Material matters: How plant proteins shape satellite cell growth in cultivated meat - Rachel Bennie
• Mutations in the vicinity of the IRAK3 guanylate cyclase centre impact its subcellular localisation and ability to modulate inflammatory signalling - Ilona Turek
• The intrinsic structural dynamics of a histone deacetylase enzyme dictate enzymatic activity and inhibition - D Flemming Hansen
• Making Deep Learning Work for Structural Biology: A National Initiative - Thomas Litfin
• Structural Insights into Dynamic Magnesium Ion Relocation in Pyruvate Aldolase - Chang Woo Kim
• Machine Learning Captures Covariant Protein Fold Management by Proteostasis in Health and Disease - William E Balch
• An AI- and Machine Learning–Driven Distributed Intelligence Framework for Protein Structure–Function Analysis Integrating Geospatial and Communication Technologies - Mulugeta Bekele
• Identifying new chemokine inhibitors by screening a library of tick protein mutants - Levi Naunton