Our research program is focused on understanding the largest class of cell surface proteins in the human body which are referred to as G protein-coupled receptors (GPCRs). These receptors are intricately involved in almost every physiological process and approximately one third of the currently prescribed medicines exert their therapeutic effects through these receptors. The overarching theme of our research is to understand the structure, function, and regulation of GPCRs, and leverage this information to design and discover novel therapeutics with minimal side-effects. Our research program employs cellular, pharmacological, and structural biology approaches to elucidate the molecular mechanisms involved in GPCR activation and signaling paradigms with an emphasis on transducer-coupling and biased agonism.